The river begins in the region now known as the Northern Wastes, flowing down into the city of Rivertown, serving as a natural border between the MPD-controlled portions of the city and the areas known as the Northwestern Reaches and Western Reaches. It empties into Lake Lawrence at the Summerland settlement.
The Juneau River was initially settled by native peoples long before the arrival of white immigrants to the Middle West. During the 19th and 20th centuries, the river was key to the founding of Rivertown as it provided an easy route for shipments throughout the area.
The river was once traversed by dozens of bridges, many of which are now destroyed or were left inoperable and in their raised state. As the bridges provide the main points of access to Rivertown, they are closely watched by the MPD, who have taken control of most of the land east of the Juneau. However the MPD does not have enough guards to effectively patrol the bridges.